http://www.article99.com/diseases-and-conditions/cancer/ en-us http://www.article99.com/rss-feeds/ Article99.com http://www.article99.com/2007/10/10/transcriptional-factors-and-regulators-57655.html All the cellular processes in living cells such as growth development morphogenesis and cellular differentiation are a product of gene expression programs involving complicated transcriptional regulation of several genes. This process of transcriptional regulation is tightly controlled and coordinated by proteins called transcriptional regulators. [...] Stephen Jones 10 Oct 2007 17:06:17 EDT http://www.article99.com/2007/Oct/Wednesday/transcriptional-factors-and-regulators-57655.html http://www.article99.com/2007/10/10/new-foxp32-exon-2-deleted-specific-antibody-57647.html FOXP3 is a master regulator of immune homeostasis expressed specifically in CD4 CD25 T regulatory cells controlling their growth development and function and generally accepted to be expressed in both mouse and human CD4 CD25 regulatory T cells. Although the emergence of regulatory T-cells and the role of FoxP3 as a critical player in their development holds great promise for the development of novel therapies for the treatment of autoimmune diseases in humans there are several questions that remain to be answered. For more details read out the article[...] Stephen Jones 10 Oct 2007 17:06:16 EDT http://www.article99.com/2007/Oct/Wednesday/new-foxp32-exon-2-deleted-specific-antibody-57647.html http://www.article99.com/2007/10/10/regulatory-t-cells-treg-57649.html Early development and differentiation of nascent T cells inside the thymus is a complex and remarkable mechanism. Around 1010 TCR variations are generated in developing lymphocyte clones through a random process of somatic cell gene reorganization. These types of T-cells require a different strategy to tame their autoimmune potential. One of many immunotolerance mechanisms that immune system has developed to distinguish between self and non-self antigens is regulatory T cells or Tregs. For more details read out the article[...] Stephen Jones 10 Oct 2007 17:06:16 EDT http://www.article99.com/2007/Oct/Wednesday/regulatory-t-cells-treg-57649.html http://www.article99.com/2007/10/10/improved-rna-interference-kits-launched-by-imgenex-57653.html RNA interference RNAi is the process of mRNA degradation that is induced by double-stranded RNA in a sequence-specific manner. RNAi has been observed in all eukaryotes from yeast to mammals. The RNAi pathway is thought to be an ancient mechanism for protecting the host and its genome against viruses and rogue genetic elements that use double-stranded RNA dsRNA in their life cycles. For more details read out the following article-[...] Stephen Jones 10 Oct 2007 17:06:16 EDT http://www.article99.com/2007/Oct/Wednesday/improved-rna-interference-kits-launched-by-imgenex-57653.html http://www.article99.com/2007/10/10/toll-like-receptortlr--unique-antibody-from-imgenex-57654.html Toll-like ReceptorTLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLRs are evolutionarily conserved and their congeners have been found in insects plants and mammals. For more details read out the following article[...] Stephen Jones 10 Oct 2007 17:06:16 EDT http://www.article99.com/2007/Oct/Wednesday/toll-like-receptortlr--unique-antibody-from-imgenex-57654.html http://www.article99.com/2007/10/10/actin-antibody-available-in-imgenex-now-57642.html Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is the monomeric subunit of microfilaments one of the three major components of the cytoskeleton and of thin filaments which are part of the contractile apparatus in muscle cells. For more details read out the article[...] Stephen Jones 10 Oct 2007 17:06:15 EDT http://www.article99.com/2007/Oct/Wednesday/actin-antibody-available-in-imgenex-now-57642.html http://www.article99.com/2007/10/10/akt-family-antibodies-from-imgenex-57643.html Akt family of serinethreonine-directed kinases regulates a diverse array of biological processes including cellular survival proliferation glucose homeostasis and vascular tone and are important molecules in mammalian cellular signaling. For more information about Akt family read out the given article[...] Stephen Jones 10 Oct 2007 17:06:15 EDT http://www.article99.com/2007/Oct/Wednesday/akt-family-antibodies-from-imgenex-57643.html http://www.article99.com/2007/10/10/apoptosis-programmed-cell-death-57644.html Apoptosis is regulated by death domain DD andor caspase recruitment domain CARD containing molecules and a caspase family of proteases. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD 1. For more details read out the article[...] Stephen Jones 10 Oct 2007 17:06:15 EDT http://www.article99.com/2007/Oct/Wednesday/apoptosis-programmed-cell-death-57644.html http://www.article99.com/2007/10/10/sensiblw-use-of-alternative-medicines-for-cancer-57629.html It cannot be denied that modern medicine has come a long way in the treatment and management of many forms of cancer. Our knowledge and treatment of these maladies is far in advance of what was common practice of years past however we have a long way to go before cancer is 100 curable. Unfortunately cancer is taking on different forms and is increasing in regularity throughout the worlds population.[...] Paul Courtney 10 Oct 2007 17:06:14 EDT http://www.article99.com/2007/Oct/Wednesday/sensiblw-use-of-alternative-medicines-for-cancer-57629.html http://www.article99.com/2007/10/10/atm-ataxia-telangiectasia-mutated-antibodies-from-imgenex-57645.html ATM the gene product mutated in the cancer susceptibility syndrome ataxiaandndashtelangiectasia is related to proteins involved in DNA repair and cell-cycle control. In undamaged cells it is present as a dimer or oligomer molecule in which the kinase domain is silent because associated with the FAT region of another ATM monomer. For more information about ATM read out the given article[...] Stephen Jones 10 Oct 2007 17:06:13 EDT http://www.article99.com/2007/Oct/Wednesday/atm-ataxia-telangiectasia-mutated-antibodies-from-imgenex-57645.html http://www.article99.com/2007/03/03/breast-cancer-walk-28071.html Cancer is one of the leading causes of death worldwide. Numerous cancer researches have been done to understand the disease better. In women breast cancer is the second most common cancer next to lung cancer.[...] Sven Ullmann 03 Mar 2007 14:02:57 EST http://www.article99.com/2007/Mar/Saturday/breast-cancer-walk-28071.html http://www.article99.com/2007/03/01/smoke-signals--pt-1--27752.html We should all smoke and I am here to tell you all why.[...] Bob Caterino 01 Mar 2007 08:31:58 EST http://www.article99.com/2007/Mar/Thursday/smoke-signals--pt-1--27752.html http://www.article99.com/2007/02/26/how-to-deal-with-a-cancer-diagnosis-27247.html andquotYouve got cancer.andquot Nothing feels more harrowing than these words. Cancer can launch a flood of emotions and a whole new world of experiences. There are ways to cope. These are mine. May they help you on your journey.[...] Zoe Routh 26 Feb 2007 09:37:10 EST http://www.article99.com/2007/Feb/Monday/how-to-deal-with-a-cancer-diagnosis-27247.html http://www.article99.com/2007/02/23/an-effective-prostate-cancer-treatment-option-26908.html If youve been told that you have prostate cancer then youve probably had The Prostate-Specific Antigen PSA Test been physically checked and probably have already had a biopsy performed. Once all this has established your condition your cancer is then assigned a score.[...] Abigail Franks 23 Feb 2007 18:00:07 EST http://www.article99.com/2007/Feb/Friday/an-effective-prostate-cancer-treatment-option-26908.html http://www.article99.com/2007/02/02/beat-and-avoid-cancer-and-illness-naturally-24210.html An article excerpted from Cancers Natural Enemy which details how to beat and avoid cancer naturally safely and effectively.[...] Tony Isaacs 02 Feb 2007 11:16:55 EST http://www.article99.com/2007/Feb/Friday/beat-and-avoid-cancer-and-illness-naturally-24210.html http://www.article99.com/2007/01/31/lymphoma-people-are-different-23163.html One of the first things I noticed after being diagnosed with lymphoma is that my lymphoma compadres appear to be a little different from those with other cancers. [...] Dave Dalton 31 Jan 2007 21:46:54 EST http://www.article99.com/2007/Jan/Wednesday/lymphoma-people-are-different-23163.html http://www.article99.com/2007/01/31/women-unite-fight-a-good-fight-22840.html There cant be a more perfect weapon against women than breast cancer. Although men do get this disease when it attacks women it seems to strike at the very essence of womanhood. The treatment and cures unfortunately do the same thing. Think about it. Our breasts are the primary target and the best defense is to remove all or part of them. Our hormones distinguish our bodies as female and they become the enemy. The treatment strips us of these hormones and our bodies stop functioning as female. Chemotherapy further takes away female aspects it stops our menses and even our hair for some of us a crown of femininity is stolen from us. [...] Dave Dalton 31 Jan 2007 21:46:53 EST http://www.article99.com/2007/Jan/Wednesday/women-unite-fight-a-good-fight-22840.html http://www.article99.com/2007/01/31/cll-misunderstood-22843.html Greetings from Chicago where I host a breast cancer education event this week. I just got back from Washington D.C. where I testified before an FDA advisory hearing of the Oncologic Drug Advisory Committee. I am still reeling from what happened there and wanted to share it with you because it says a lot about where we are with drug development and cancer drug approvals. [...] Dave Dalton 31 Jan 2007 21:46:53 EST http://www.article99.com/2007/Jan/Wednesday/cll-misunderstood-22843.html http://www.article99.com/2007/01/31/genta-answers-our-questions-about-genasense-22844.html If you have been following this blog you know I am on a campaign to get some answers from the FDA on how they evaluate potential new drugs. [...] Dave Dalton 31 Jan 2007 21:46:53 EST http://www.article99.com/2007/Jan/Wednesday/genta-answers-our-questions-about-genasense-22844.html http://www.article99.com/2007/01/31/looking-behind-the-fda-curtain-22845.html Thank you for all the comments to my blog postings about the FDA and its process for reviewing Genasense. Its still up to the FDA to approve it or not. It is an uphill battle as the advisory committee voted 7-3 against approval. The earlier blog posting and the very expert comments from so many CLLers will provide you with a all the background if you are new to the discussion. [...] Dave Dalton 31 Jan 2007 21:46:53 EST http://www.article99.com/2007/Jan/Wednesday/looking-behind-the-fda-curtain-22845.html